| Tuscaloosa to Southchase (Florida) | 494.94 mi (796.53 km) |
| Tuscaloosa to Southern Pines (North Carolina) | 483.26 mi (777.73 km) |
| Tuscaloosa to Southfield (Michigan) | 679.38 mi (1,093.36 km) |
| Tuscaloosa to Southgate (Michigan) | 662.98 mi (1,066.97 km) |
| Tuscaloosa to Southlake (Texas) | 557.19 mi (896.71 km) |
| Tuscaloosa to Spanaway (Washington) | 2,053.24 mi (3,304.37 km) |
| Tuscaloosa to Spanish Fork (Utah) | 1,412.86 mi (2,273.78 km) |
| Tuscaloosa to Spanish Lake (Missouri) | 411.88 mi (662.85 km) |
| Tuscaloosa to Spanish Springs (Nevada) | 1,830.18 mi (2,945.38 km) |
| Tuscaloosa to Sparks (Nevada) | 1,832.28 mi (2,948.77 km) |
| Tuscaloosa to Spartanburg (South Carolina) | 341.54 mi (549.65 km) |
| Tuscaloosa to Spearfish (South Dakota) | 1,167.67 mi (1,879.18 km) |
| Tuscaloosa to Speedway (Indiana) | 458.69 mi (738.19 km) |
| Tuscaloosa to Spencer (Iowa) | 799.52 mi (1,286.70 km) |
| Tuscaloosa to Spokane (Washington) | 1,844.21 mi (2,967.97 km) |
