| Tupelo to Yonkers (New York) | 933.47 mi (1,502.28 km) |
| Tupelo to Yorba Linda (California) | 1,656.39 mi (2,665.70 km) |
| Tupelo to York (Pennsylvania) | 768.41 mi (1,236.63 km) |
| Tupelo to Yorktown (Indiana) | 445.25 mi (716.57 km) |
| Tupelo to Yorkville (Illinois) | 510.63 mi (821.78 km) |
| Tupelo to Youngstown (Ohio) | 646.07 mi (1,039.74 km) |
| Tupelo to Youngsville (Louisiana) | 345.75 mi (556.43 km) |
| Tupelo to Ypsilanti (Michigan) | 616.54 mi (992.23 km) |
| Tupelo to Yuba City (California) | 1,843.20 mi (2,966.35 km) |
| Tupelo to Yucaipa (California) | 1,613.60 mi (2,596.83 km) |
| Tupelo to Yucca Valley (California) | 1,577.52 mi (2,538.77 km) |
| Tupelo to Yukon (Oklahoma) | 518.91 mi (835.10 km) |
| Tupelo to Yulee (Florida) | 487.15 mi (784.00 km) |
| Tupelo to Yuma (Arizona) | 1,489.09 mi (2,396.46 km) |
| Tupelo to Zachary (Louisiana) | 286.56 mi (461.17 km) |
