| Tupelo to University Place (Washington) | 1,962.39 mi (3,158.17 km) |
| Tupelo to Upland (California) | 1,647.67 mi (2,651.66 km) |
| Tupelo to Upper Arlington (Ohio) | 505.21 mi (813.06 km) |
| Tupelo to Upper Grand Lagoon (Florida) | 332.86 mi (535.69 km) |
| Tupelo to Upper Montclair (New Jersey) | 914.68 mi (1,472.03 km) |
| Tupelo to Urbana (Illinois) | 404.68 mi (651.26 km) |
| Tupelo to Urbana (Maryland) | 719.76 mi (1,158.34 km) |
| Tupelo to Urbana (Ohio) | 487.50 mi (784.55 km) |
| Tupelo to Urbandale (Iowa) | 578.49 mi (930.99 km) |
| Tupelo to Utica (New York) | 947.92 mi (1,525.53 km) |
| Tupelo to Uvalde (Texas) | 736.40 mi (1,185.12 km) |
| Tupelo to Vacaville (California) | 1,861.61 mi (2,995.97 km) |
| Tupelo to Vadnais Heights (Minnesota) | 780.02 mi (1,255.32 km) |
| Tupelo to Vail (Arizona) | 1,277.45 mi (2,055.86 km) |
| Tupelo to Valdosta (Georgia) | 395.67 mi (636.77 km) |
