| Tupelo to Sunset (Florida) | 774.88 mi (1,247.05 km) |
| Tupelo to Superior (Colorado) | 984.27 mi (1,584.02 km) |
| Tupelo to Superior (Wisconsin) | 876.13 mi (1,409.99 km) |
| Tupelo to Surprise (Arizona) | 1,356.61 mi (2,183.25 km) |
| Tupelo to Susanville (California) | 1,791.56 mi (2,883.25 km) |
| Tupelo to Sussex (Wisconsin) | 613.15 mi (986.77 km) |
| Tupelo to Suwanee (Georgia) | 267.01 mi (429.71 km) |
| Tupelo to Swansea (Illinois) | 303.92 mi (489.11 km) |
| Tupelo to Sweetwater (Florida) | 770.06 mi (1,239.29 km) |
| Tupelo to Sweetwater (Texas) | 684.79 mi (1,102.06 km) |
| Tupelo to Sycamore (Illinois) | 533.86 mi (859.16 km) |
| Tupelo to Sylacauga (Alabama) | 160.78 mi (258.75 km) |
| Tupelo to Sylvania (Ohio) | 582.06 mi (936.74 km) |
| Tupelo to Syosset (New York) | 947.16 mi (1,524.30 km) |
| Tupelo to Syracuse (New York) | 908.44 mi (1,461.99 km) |
