| Tupelo to Stony Brook (New York) | 967.58 mi (1,557.17 km) |
| Tupelo to Storm Lake (Iowa) | 675.57 mi (1,087.23 km) |
| Tupelo to Storrs (Connecticut) | 1,034.51 mi (1,664.89 km) |
| Tupelo to Stoughton (Wisconsin) | 598.55 mi (963.28 km) |
| Tupelo to Stow (Ohio) | 621.45 mi (1,000.12 km) |
| Tupelo to Streamwood (Illinois) | 536.43 mi (863.30 km) |
| Tupelo to Streator (Illinois) | 473.69 mi (762.32 km) |
| Tupelo to Streetsboro (Ohio) | 627.78 mi (1,010.31 km) |
| Tupelo to Strongsville (Ohio) | 615.01 mi (989.76 km) |
| Tupelo to Stuart (Florida) | 701.53 mi (1,129.00 km) |
| Tupelo to Stuarts Draft (Virginia) | 599.42 mi (964.67 km) |
| Tupelo to Sturgis (Michigan) | 550.50 mi (885.95 km) |
| Tupelo to Suamico (Wisconsin) | 717.10 mi (1,154.06 km) |
| Tupelo to Sudley (Virginia) | 696.88 mi (1,121.52 km) |
| Tupelo to Suffern (New York) | 925.49 mi (1,489.44 km) |
