| Tupelo to St. Petersburg (Florida) | 573.50 mi (922.96 km) |
| Tupelo to St. Simons (Georgia) | 477.28 mi (768.11 km) |
| Tupelo to Stafford (Texas) | 512.97 mi (825.55 km) |
| Tupelo to Stallings (North Carolina) | 462.11 mi (743.70 km) |
| Tupelo to Stamford (Connecticut) | 952.64 mi (1,533.13 km) |
| Tupelo to Stanford (California) | 1,875.39 mi (3,018.15 km) |
| Tupelo to Stanton (California) | 1,669.95 mi (2,687.53 km) |
| Tupelo to Star (Idaho) | 1,617.15 mi (2,602.55 km) |
| Tupelo to Starkville (Mississippi) | 56.14 mi (90.34 km) |
| Tupelo to State College (Pennsylvania) | 746.10 mi (1,200.73 km) |
| Tupelo to Staten Island (New York) | 909.64 mi (1,463.93 km) |
| Tupelo to Statesboro (Georgia) | 420.86 mi (677.31 km) |
| Tupelo to Statesville (North Carolina) | 456.75 mi (735.07 km) |
| Tupelo to Staunton (Virginia) | 601.94 mi (968.73 km) |
| Tupelo to Steamboat Springs (Colorado) | 1,079.45 mi (1,737.21 km) |
