| Tupelo to Southchase (Florida) | 594.10 mi (956.11 km) |
| Tupelo to Southern Pines (North Carolina) | 533.30 mi (858.26 km) |
| Tupelo to Southfield (Michigan) | 639.49 mi (1,029.16 km) |
| Tupelo to Southgate (Michigan) | 624.60 mi (1,005.19 km) |
| Tupelo to Southlake (Texas) | 492.70 mi (792.92 km) |
| Tupelo to Spanaway (Washington) | 1,954.76 mi (3,145.88 km) |
| Tupelo to Spanish Fork (Utah) | 1,319.58 mi (2,123.66 km) |
| Tupelo to Spanish Lake (Missouri) | 322.81 mi (519.50 km) |
| Tupelo to Spanish Springs (Nevada) | 1,738.94 mi (2,798.56 km) |
| Tupelo to Sparks (Nevada) | 1,741.18 mi (2,802.16 km) |
| Tupelo to Spartanburg (South Carolina) | 389.81 mi (627.34 km) |
| Tupelo to Spearfish (South Dakota) | 1,068.17 mi (1,719.06 km) |
| Tupelo to Speedway (Indiana) | 405.50 mi (652.58 km) |
| Tupelo to Spencer (Iowa) | 703.82 mi (1,132.69 km) |
| Tupelo to Spokane (Washington) | 1,745.05 mi (2,808.39 km) |
