| Tupelo to Smithville (Missouri) | 479.03 mi (770.93 km) |
| Tupelo to Smyrna (Delaware) | 803.86 mi (1,293.69 km) |
| Tupelo to Smyrna (Georgia) | 242.86 mi (390.84 km) |
| Tupelo to Smyrna (Tennessee) | 171.23 mi (275.57 km) |
| Tupelo to Snellville (Georgia) | 272.10 mi (437.90 km) |
| Tupelo to Snoqualmie (Washington) | 1,936.39 mi (3,116.32 km) |
| Tupelo to Snyder (Texas) | 709.56 mi (1,141.92 km) |
| Tupelo to Socastee (South Carolina) | 558.33 mi (898.55 km) |
| Tupelo to Socorro (Texas) | 1,031.00 mi (1,659.24 km) |
| Tupelo to Soddy-Daisy (Tennessee) | 213.16 mi (343.05 km) |
| Tupelo to Solana Beach (California) | 1,638.03 mi (2,636.15 km) |
| Tupelo to Soledad (California) | 1,835.04 mi (2,953.21 km) |
| Tupelo to Solon (Ohio) | 632.08 mi (1,017.24 km) |
| Tupelo to Somers Point (New Jersey) | 854.56 mi (1,375.28 km) |
| Tupelo to Somerset (Kentucky) | 302.11 mi (486.19 km) |
