| Tupelo to Siloam Springs (Arkansas) | 353.00 mi (568.09 km) |
| Tupelo to Silver Firs (Washington) | 1,956.63 mi (3,148.88 km) |
| Tupelo to Silver Spring (Maryland) | 726.22 mi (1,168.74 km) |
| Tupelo to Silver Springs Shores (Florida) | 531.61 mi (855.54 km) |
| Tupelo to Silverdale (Washington) | 1,976.70 mi (3,181.19 km) |
| Tupelo to Silverton (Oregon) | 1,939.85 mi (3,121.88 km) |
| Tupelo to Simi Valley (California) | 1,707.65 mi (2,748.20 km) |
| Tupelo to Simpsonville (South Carolina) | 370.00 mi (595.45 km) |
| Tupelo to Sioux City (Iowa) | 702.98 mi (1,131.34 km) |
| Tupelo to Sioux Falls (South Dakota) | 770.68 mi (1,240.29 km) |
| Tupelo to Skokie (Illinois) | 539.32 mi (867.95 km) |
| Tupelo to Sleepy Hollow (New York) | 937.55 mi (1,508.84 km) |
| Tupelo to Slidell (Louisiana) | 281.79 mi (453.50 km) |
| Tupelo to Smithfield (North Carolina) | 594.35 mi (956.52 km) |
| Tupelo to Smithfield (Utah) | 1,355.51 mi (2,181.48 km) |
