| Tupelo to Seymour (Indiana) | 359.55 mi (578.63 km) |
| Tupelo to Seymour (Tennessee) | 301.91 mi (485.88 km) |
| Tupelo to Shady Hills (Florida) | 545.12 mi (877.29 km) |
| Tupelo to Shafter (California) | 1,722.33 mi (2,771.83 km) |
| Tupelo to Shaker Heights (Ohio) | 632.96 mi (1,018.65 km) |
| Tupelo to Shakopee (Minnesota) | 768.28 mi (1,236.43 km) |
| Tupelo to Sharon (Pennsylvania) | 658.02 mi (1,058.98 km) |
| Tupelo to Sharonville (Ohio) | 420.90 mi (677.38 km) |
| Tupelo to Shasta Lake (California) | 1,885.01 mi (3,033.63 km) |
| Tupelo to Shawnee (Kansas) | 469.90 mi (756.23 km) |
| Tupelo to Shawnee (Oklahoma) | 472.86 mi (760.99 km) |
| Tupelo to Sheboygan (Wisconsin) | 656.57 mi (1,056.65 km) |
| Tupelo to Shelby (North Carolina) | 413.80 mi (665.95 km) |
| Tupelo to Shelbyville (Indiana) | 398.68 mi (641.61 km) |
| Tupelo to Shelbyville (Kentucky) | 334.77 mi (538.76 km) |
