| Tupelo to Scottsbluff (Nebraska) | 964.90 mi (1,552.85 km) |
| Tupelo to Scottsboro (Alabama) | 155.01 mi (249.46 km) |
| Tupelo to Scottsdale (Arizona) | 1,323.19 mi (2,129.47 km) |
| Tupelo to Scranton (Pennsylvania) | 865.31 mi (1,392.59 km) |
| Tupelo to Seabrook (Maryland) | 734.05 mi (1,181.34 km) |
| Tupelo to Seabrook (Texas) | 491.05 mi (790.26 km) |
| Tupelo to Seaford (New York) | 943.58 mi (1,518.54 km) |
| Tupelo to Seagoville (Texas) | 463.90 mi (746.58 km) |
| Tupelo to Seal Beach (California) | 1,674.89 mi (2,695.47 km) |
| Tupelo to Searcy (Arkansas) | 183.24 mi (294.90 km) |
| Tupelo to Seaside (California) | 1,860.36 mi (2,993.95 km) |
| Tupelo to SeaTac (Washington) | 1,955.35 mi (3,146.83 km) |
| Tupelo to Seattle (Washington) | 1,959.79 mi (3,153.98 km) |
| Tupelo to Sebastian (Florida) | 662.46 mi (1,066.12 km) |
| Tupelo to Sebring (Florida) | 637.22 mi (1,025.50 km) |
