| Tupelo to Santa Paula (California) | 1,724.61 mi (2,775.50 km) |
| Tupelo to Santa Rosa (California) | 1,901.44 mi (3,060.08 km) |
| Tupelo to Santaquin (Utah) | 1,325.87 mi (2,133.77 km) |
| Tupelo to Santee (California) | 1,624.39 mi (2,614.21 km) |
| Tupelo to Sapulpa (Oklahoma) | 433.21 mi (697.18 km) |
| Tupelo to Saraland (Alabama) | 239.23 mi (385.00 km) |
| Tupelo to Sarasota (Florida) | 603.17 mi (970.70 km) |
| Tupelo to Sarasota Springs (Florida) | 607.32 mi (977.39 km) |
| Tupelo to Saratoga (California) | 1,868.34 mi (3,006.81 km) |
| Tupelo to Saratoga Springs (New York) | 1,007.55 mi (1,621.50 km) |
| Tupelo to Saratoga Springs (Utah) | 1,336.85 mi (2,151.45 km) |
| Tupelo to Sartell (Minnesota) | 835.82 mi (1,345.12 km) |
| Tupelo to Satellite Beach (Florida) | 638.20 mi (1,027.08 km) |
| Tupelo to Sauk Rapids (Minnesota) | 833.28 mi (1,341.03 km) |
| Tupelo to Sault Ste. Marie (Michigan) | 874.08 mi (1,406.69 km) |
