| Tupelo to Reedley (California) | 1,729.27 mi (2,782.99 km) |
| Tupelo to Reidsville (North Carolina) | 530.21 mi (853.28 km) |
| Tupelo to Reisterstown (Maryland) | 749.04 mi (1,205.47 km) |
| Tupelo to Rendon (Texas) | 503.89 mi (810.93 km) |
| Tupelo to Reno (Nevada) | 1,748.15 mi (2,813.38 km) |
| Tupelo to Renton (Washington) | 1,951.17 mi (3,140.11 km) |
| Tupelo to Republic (Missouri) | 330.68 mi (532.17 km) |
| Tupelo to Reston (Virginia) | 708.73 mi (1,140.58 km) |
| Tupelo to Revere (Massachusetts) | 1,110.23 mi (1,786.75 km) |
| Tupelo to Rexburg (Idaho) | 1,395.73 mi (2,246.22 km) |
| Tupelo to Reynoldsburg (Ohio) | 511.16 mi (822.63 km) |
| Tupelo to Rialto (California) | 1,632.33 mi (2,626.98 km) |
| Tupelo to Richardson (Texas) | 467.53 mi (752.42 km) |
| Tupelo to Richfield (Minnesota) | 771.58 mi (1,241.74 km) |
| Tupelo to Richfield (Wisconsin) | 620.19 mi (998.10 km) |
