| Tupelo to Oskaloosa (Iowa) | 529.95 mi (852.88 km) |
| Tupelo to Oswego (Illinois) | 512.72 mi (825.14 km) |
| Tupelo to Oswego (New York) | 912.24 mi (1,468.10 km) |
| Tupelo to Otsego (Minnesota) | 802.52 mi (1,291.54 km) |
| Tupelo to Ottawa (Illinois) | 489.64 mi (788.00 km) |
| Tupelo to Ottawa (Kansas) | 470.26 mi (756.80 km) |
| Tupelo to Ottumwa (Iowa) | 508.01 mi (817.57 km) |
| Tupelo to Overland (Missouri) | 319.12 mi (513.57 km) |
| Tupelo to Overland Park (Kansas) | 459.12 mi (738.88 km) |
| Tupelo to Overlea (Maryland) | 760.89 mi (1,224.53 km) |
| Tupelo to Oviedo (Florida) | 589.57 mi (948.83 km) |
| Tupelo to Owasso (Oklahoma) | 423.90 mi (682.20 km) |
| Tupelo to Owatonna (Minnesota) | 719.85 mi (1,158.48 km) |
| Tupelo to Owensboro (Kentucky) | 257.34 mi (414.15 km) |
| Tupelo to Owings Mills (Maryland) | 748.88 mi (1,205.21 km) |
