| Tupelo to Orangeburg (South Carolina) | 454.19 mi (730.95 km) |
| Tupelo to Orangevale (California) | 1,820.85 mi (2,930.38 km) |
| Tupelo to Orchards (Washington) | 1,937.21 mi (3,117.64 km) |
| Tupelo to Orcutt (California) | 1,795.92 mi (2,890.25 km) |
| Tupelo to Oregon (Ohio) | 585.86 mi (942.85 km) |
| Tupelo to Oregon (Wisconsin) | 599.13 mi (964.20 km) |
| Tupelo to Oregon City (Oregon) | 1,935.28 mi (3,114.53 km) |
| Tupelo to Orem (Utah) | 1,325.06 mi (2,132.48 km) |
| Tupelo to Orinda (California) | 1,874.33 mi (3,016.44 km) |
| Tupelo to Orland Park (Illinois) | 509.23 mi (819.53 km) |
| Tupelo to Orlando (Florida) | 591.63 mi (952.14 km) |
| Tupelo to Ormond Beach (Florida) | 564.30 mi (908.16 km) |
| Tupelo to Oro Valley (Arizona) | 1,287.71 mi (2,072.37 km) |
| Tupelo to Oroville (California) | 1,839.43 mi (2,960.28 km) |
| Tupelo to Oshkosh (Wisconsin) | 673.96 mi (1,084.64 km) |
