| Tupelo to Olympia (Washington) | 1,975.33 mi (3,178.99 km) |
| Tupelo to Olympia Heights (Florida) | 774.45 mi (1,246.36 km) |
| Tupelo to Omaha (Nebraska) | 626.70 mi (1,008.57 km) |
| Tupelo to On Top of the World Designated Place (Florida) | 520.21 mi (837.19 km) |
| Tupelo to Onalaska (Wisconsin) | 677.66 mi (1,090.59 km) |
| Tupelo to Oneida (New York) | 929.34 mi (1,495.63 km) |
| Tupelo to Oneonta (New York) | 929.67 mi (1,496.16 km) |
| Tupelo to Ontario (California) | 1,645.43 mi (2,648.07 km) |
| Tupelo to Ontario (Oregon) | 1,646.09 mi (2,649.12 km) |
| Tupelo to Opa-locka (Florida) | 768.24 mi (1,236.37 km) |
| Tupelo to Opelika (Alabama) | 223.00 mi (358.88 km) |
| Tupelo to Opelousas (Louisiana) | 324.15 mi (521.68 km) |
| Tupelo to Orange (California) | 1,660.19 mi (2,671.81 km) |
| Tupelo to Orange (Texas) | 410.42 mi (660.50 km) |
| Tupelo to Orange City (Florida) | 572.15 mi (920.79 km) |
