| Tupelo to Odenton (Maryland) | 744.09 mi (1,197.49 km) |
| Tupelo to Odessa (Texas) | 804.59 mi (1,294.86 km) |
| Tupelo to Ogden (Utah) | 1,352.33 mi (2,176.37 km) |
| Tupelo to Oildale (California) | 1,713.15 mi (2,757.05 km) |
| Tupelo to Ojus (Florida) | 768.95 mi (1,237.51 km) |
| Tupelo to Okemos (Michigan) | 627.71 mi (1,010.21 km) |
| Tupelo to Oklahoma City (Oklahoma) | 504.49 mi (811.90 km) |
| Tupelo to Okmulgee (Oklahoma) | 422.27 mi (679.58 km) |
| Tupelo to Olathe (Kansas) | 464.27 mi (747.18 km) |
| Tupelo to Old Jamestown (Missouri) | 327.31 mi (526.75 km) |
| Tupelo to Oldsmar (Florida) | 559.26 mi (900.05 km) |
| Tupelo to Olean (New York) | 776.30 mi (1,249.34 km) |
| Tupelo to Olive Branch (Mississippi) | 79.40 mi (127.79 km) |
| Tupelo to Olivehurst (California) | 1,838.81 mi (2,959.28 km) |
| Tupelo to Olney (Maryland) | 727.69 mi (1,171.11 km) |
