| Tupelo to Enterprise (Nevada) | 1,497.27 mi (2,409.63 km) |
| Tupelo to Enumclaw (Washington) | 1,936.95 mi (3,117.21 km) |
| Tupelo to Ephrata (Pennsylvania) | 801.11 mi (1,289.26 km) |
| Tupelo to Erie (Colorado) | 980.64 mi (1,578.18 km) |
| Tupelo to Erie (Pennsylvania) | 716.88 mi (1,153.70 km) |
| Tupelo to Erlanger (Kentucky) | 400.08 mi (643.87 km) |
| Tupelo to Escanaba (Michigan) | 797.78 mi (1,283.91 km) |
| Tupelo to Escondido (California) | 1,625.68 mi (2,616.27 km) |
| Tupelo to Española (New Mexico) | 985.56 mi (1,586.11 km) |
| Tupelo to Essex (Maryland) | 762.73 mi (1,227.50 km) |
| Tupelo to Essex Junction (Vermont) | 1,089.54 mi (1,753.44 km) |
| Tupelo to Estelle (Louisiana) | 316.05 mi (508.63 km) |
| Tupelo to Estero (Florida) | 681.19 mi (1,096.27 km) |
| Tupelo to Euclid (Ohio) | 640.10 mi (1,030.14 km) |
| Tupelo to Eufaula (Alabama) | 263.68 mi (424.35 km) |
