| Tupelo to Elyria (Ohio) | 609.39 mi (980.72 km) |
| Tupelo to Emeryville (California) | 1,880.69 mi (3,026.68 km) |
| Tupelo to Emmaus (Pennsylvania) | 844.24 mi (1,358.67 km) |
| Tupelo to Emporia (Kansas) | 503.74 mi (810.69 km) |
| Tupelo to Encinitas (California) | 1,637.51 mi (2,635.32 km) |
| Tupelo to Endicott (New York) | 873.54 mi (1,405.83 km) |
| Tupelo to Endwell (New York) | 876.12 mi (1,409.97 km) |
| Tupelo to Englewood (Colorado) | 969.87 mi (1,560.85 km) |
| Tupelo to Englewood (Florida) | 630.61 mi (1,014.87 km) |
| Tupelo to Englewood (New Jersey) | 926.84 mi (1,491.61 km) |
| Tupelo to Englewood (Ohio) | 456.97 mi (735.42 km) |
| Tupelo to Enid (Oklahoma) | 535.56 mi (861.90 km) |
| Tupelo to Ennis (Texas) | 475.59 mi (765.39 km) |
| Tupelo to Ensley (Florida) | 272.26 mi (438.16 km) |
| Tupelo to Enterprise (Alabama) | 263.40 mi (423.90 km) |
