| Tupelo to Des Plaines (Illinois) | 538.42 mi (866.50 km) |
| Tupelo to Desert Hot Springs (California) | 1,586.10 mi (2,552.58 km) |
| Tupelo to DeSoto (Texas) | 482.70 mi (776.82 km) |
| Tupelo to Destin (Florida) | 298.45 mi (480.31 km) |
| Tupelo to Destrehan (Louisiana) | 312.56 mi (503.02 km) |
| Tupelo to Detroit (Michigan) | 637.92 mi (1,026.63 km) |
| Tupelo to Diamond Bar (California) | 1,657.72 mi (2,667.85 km) |
| Tupelo to Diamond Springs (California) | 1,800.26 mi (2,897.24 km) |
| Tupelo to Dickinson (North Dakota) | 1,138.78 mi (1,832.68 km) |
| Tupelo to Dickinson (Texas) | 498.29 mi (801.92 km) |
| Tupelo to Dickson (Tennessee) | 146.01 mi (234.98 km) |
| Tupelo to Difficult Run (Virginia) | 707.35 mi (1,138.37 km) |
| Tupelo to Dinuba (California) | 1,726.84 mi (2,779.09 km) |
| Tupelo to Discovery Bay (California) | 1,842.66 mi (2,965.47 km) |
| Tupelo to Dix Hills (New York) | 954.71 mi (1,536.45 km) |
