| Tupelo to Delaware (Ohio) | 518.90 mi (835.08 km) |
| Tupelo to Delhi (California) | 1,799.13 mi (2,895.43 km) |
| Tupelo to Delray Beach (Florida) | 745.61 mi (1,199.94 km) |
| Tupelo to Deltona (Florida) | 576.87 mi (928.39 km) |
| Tupelo to Deming (New Mexico) | 1,105.91 mi (1,779.79 km) |
| Tupelo to Denison (Texas) | 450.72 mi (725.37 km) |
| Tupelo to Dent (Ohio) | 407.94 mi (656.51 km) |
| Tupelo to Denton (Texas) | 488.47 mi (786.11 km) |
| Tupelo to Dentsville (South Carolina) | 444.67 mi (715.62 km) |
| Tupelo to Denver (Colorado) | 966.30 mi (1,555.11 km) |
| Tupelo to Depew (New York) | 804.94 mi (1,295.43 km) |
| Tupelo to Derby (Connecticut) | 981.51 mi (1,579.59 km) |
| Tupelo to Derby (Kansas) | 528.01 mi (849.74 km) |
| Tupelo to Des Moines (Iowa) | 570.13 mi (917.54 km) |
| Tupelo to Des Moines (Washington) | 1,955.14 mi (3,146.49 km) |
