| Syston to Southern Pines (North Carolina) | 3,871.69 mi (6,230.88 km) |
| Syston to Southfield (Michigan) | 3,680.91 mi (5,923.85 km) |
| Syston to Southgate (Michigan) | 3,691.27 mi (5,940.53 km) |
| Syston to Southlake (Texas) | 4,679.81 mi (7,531.42 km) |
| Syston to Spanaway (Washington) | 4,726.01 mi (7,605.78 km) |
| Syston to Spanish Fork (Utah) | 4,804.03 mi (7,731.34 km) |
| Syston to Spanish Lake (Missouri) | 4,120.35 mi (6,631.07 km) |
| Syston to Spanish Springs (Nevada) | 5,076.73 mi (8,170.21 km) |
| Syston to Sparks (Nevada) | 5,082.90 mi (8,180.13 km) |
| Syston to Spartanburg (South Carolina) | 3,985.23 mi (6,413.61 km) |
| Syston to Spearfish (South Dakota) | 4,316.47 mi (6,946.68 km) |
| Syston to Speedway (Indiana) | 3,920.81 mi (6,309.93 km) |
| Syston to Spencer (Iowa) | 4,087.78 mi (6,578.65 km) |
| Syston to Spokane (Washington) | 4,559.47 mi (7,337.75 km) |
| Syston to Spokane Valley (Washington) | 4,554.22 mi (7,329.31 km) |
