| Syston to Sestu | 1,044.37 mi (1,680.75 km) |
| Syston to Settimo Torinese | 658.28 mi (1,059.40 km) |
| Syston to Seveso | 670.13 mi (1,078.47 km) |
| Syston to Sezze | 1,016.87 mi (1,636.49 km) |
| Syston to Siano | 1,105.77 mi (1,779.56 km) |
| Syston to Siena | 863.22 mi (1,389.22 km) |
| Syston to Signa | 830.66 mi (1,336.82 km) |
| Syston to Silea | 773.79 mi (1,245.29 km) |
| Syston to Silvi Paese | 992.46 mi (1,597.21 km) |
| Syston to Sinalunga | 881.05 mi (1,417.91 km) |
| Syston to Siniscola | 979.08 mi (1,575.68 km) |
| Syston to Sinnai | 1,046.62 mi (1,684.37 km) |
| Syston to Siracusa | 1,338.03 mi (2,153.34 km) |
| Syston to Solaro | 670.00 mi (1,078.25 km) |
| Syston to Soliera | 774.01 mi (1,245.65 km) |
