| Syracuse to Savignano sul Rubicone | 4,198.99 mi (6,757.63 km) |
| Syracuse to Savona | 4,026.87 mi (6,480.63 km) |
| Syracuse to Scafati | 4,418.81 mi (7,111.39 km) |
| Syracuse to Scalea | 4,511.22 mi (7,260.11 km) |
| Syracuse to Scandiano | 4,109.23 mi (6,613.16 km) |
| Syracuse to Scandicci | 4,161.25 mi (6,696.89 km) |
| Syracuse to Schio | 4,095.90 mi (6,591.71 km) |
| Syracuse to Sciacca | 4,487.90 mi (7,222.58 km) |
| Syracuse to Scicli | 4,588.79 mi (7,384.95 km) |
| Syracuse to Scordia | 4,574.11 mi (7,361.31 km) |
| Syracuse to Scorze | 4,131.84 mi (6,649.55 km) |
| Syracuse to Sedico | 4,111.44 mi (6,616.72 km) |
| Syracuse to Sedriano | 4,005.43 mi (6,446.12 km) |
| Syracuse to Segni | 4,317.74 mi (6,948.73 km) |
| Syracuse to Segrate | 4,018.85 mi (6,467.72 km) |
