| Syracuse to Sacile | 4,133.19 mi (6,651.73 km) |
| Syracuse to Sala Consilina | 4,478.83 mi (7,207.98 km) |
| Syracuse to Salemi | 4,462.61 mi (7,181.88 km) |
| Syracuse to Salerno | 4,431.73 mi (7,132.18 km) |
| Syracuse to Salo | 4,066.14 mi (6,543.81 km) |
| Syracuse to Salsomaggiore Terme | 4,071.58 mi (6,552.58 km) |
| Syracuse to Saluzzo | 3,973.01 mi (6,393.94 km) |
| Syracuse to Salzano | 4,133.58 mi (6,652.36 km) |
| Syracuse to Samarate | 3,993.09 mi (6,426.26 km) |
| Syracuse to San Benedetto del Tronto | 4,304.75 mi (6,927.83 km) |
| Syracuse to San Biagio di Callalta | 4,138.72 mi (6,660.63 km) |
| Syracuse to San Bonifacio | 4,104.29 mi (6,605.22 km) |
| Syracuse to San Casciano in Val di Pesa | 4,164.75 mi (6,702.51 km) |
| Syracuse to San Cataldo | 4,528.42 mi (7,287.79 km) |
| Syracuse to San Cesareo | 4,303.31 mi (6,925.52 km) |
