| Syracuse to Orbetello | 4,211.80 mi (6,778.23 km) |
| Syracuse to Oria | 4,560.53 mi (7,339.47 km) |
| Syracuse to Oristano | 4,194.35 mi (6,750.15 km) |
| Syracuse to Orta Nova | 4,445.72 mi (7,154.69 km) |
| Syracuse to Orte | 4,260.81 mi (6,857.11 km) |
| Syracuse to Ortona | 4,349.91 mi (7,000.51 km) |
| Syracuse to Orvieto | 4,239.24 mi (6,822.40 km) |
| Syracuse to Orzinuovi | 4,048.54 mi (6,515.50 km) |
| Syracuse to Osimo | 4,267.40 mi (6,867.72 km) |
| Syracuse to Ospitaletto | 4,048.76 mi (6,515.85 km) |
| Syracuse to Ostuni | 4,548.74 mi (7,320.49 km) |
| Syracuse to Ottaviano | 4,412.91 mi (7,101.89 km) |
| Syracuse to Ovada | 4,022.02 mi (6,472.81 km) |
| Syracuse to Ozieri | 4,186.68 mi (6,737.81 km) |
| Syracuse to Paceco | 4,444.82 mi (7,153.25 km) |
