| Syosset to Southchase (Florida) | 968.30 mi (1,558.33 km) |
| Syosset to Southern Pines (North Carolina) | 503.90 mi (810.95 km) |
| Syosset to Southfield (Michigan) | 516.42 mi (831.10 km) |
| Syosset to Southgate (Michigan) | 510.86 mi (822.14 km) |
| Syosset to Southlake (Texas) | 1,409.59 mi (2,268.52 km) |
| Syosset to Spanaway (Washington) | 2,430.81 mi (3,912.01 km) |
| Syosset to Spanish Fork (Utah) | 1,989.46 mi (3,201.73 km) |
| Syosset to Spanish Lake (Missouri) | 896.34 mi (1,442.52 km) |
| Syosset to Spanish Springs (Nevada) | 2,407.84 mi (3,875.05 km) |
| Syosset to Sparks (Nevada) | 2,411.92 mi (3,881.61 km) |
| Syosset to Spartanburg (South Carolina) | 612.31 mi (985.42 km) |
| Syosset to Spearfish (South Dakota) | 1,552.02 mi (2,497.73 km) |
| Syosset to Speedway (Indiana) | 674.71 mi (1,085.84 km) |
| Syosset to Spencer (Iowa) | 1,120.44 mi (1,803.17 km) |
| Syosset to Spokane (Washington) | 2,194.55 mi (3,531.78 km) |
