| Dallas (Texas) to Des Moines | 630.83 mi (1,015.23 km) |
| Atlanta (Georgia) to Des Moines | 736.49 mi (1,185.27 km) |
| Houston (Texas) to Des Moines | 820.40 mi (1,320.31 km) |
| Washington (District of Columbia) to Des Moines | 892.93 mi (1,437.03 km) |
| Baltimore (Maryland) to Des Moines | 905.85 mi (1,457.83 km) |
| Philadelphia (Pennsylvania) to Des Moines | 970.68 mi (1,562.15 km) |
| Brooklyn (New York) to Des Moines | 1,023.26 mi (1,646.77 km) |
| New York (New York) to Des Moines | 1,024.01 mi (1,647.98 km) |
| Queens (New York) to Des Moines | 1,029.92 mi (1,657.50 km) |
| Tampa (Florida) to Des Moines | 1,129.86 mi (1,818.33 km) |
| Phoenix (Arizona) to Des Moines | 1,149.62 mi (1,850.13 km) |
| Boston (Massachusetts) to Des Moines | 1,155.35 mi (1,859.35 km) |
| Las Vegas (Nevada) to Des Moines | 1,217.59 mi (1,959.52 km) |
| Miami (Florida) to Des Moines | 1,331.93 mi (2,143.53 km) |
| Riverside (California) to Des Moines | 1,396.50 mi (2,247.44 km) |
| San Diego (California) to Des Moines | 1,421.79 mi (2,288.14 km) |
| Los Angeles (California) to Des Moines | 1,441.49 mi (2,319.85 km) |
| Seattle (Washington) to Des Moines | 1,463.67 mi (2,355.56 km) |
| Portland (Oregon) to Des Moines | 1,471.26 mi (2,367.76 km) |
| San Francisco (California) to Des Moines | 1,548.70 mi (2,492.39 km) |
| Minneapolis (Minnesota) to Des Moines | 234.93 mi (378.08 km) |
| St. Louis (Missouri) to Des Moines | 269.77 mi (434.15 km) |
| Chicago (Illinois) to Des Moines | 306.06 mi (492.56 km) |
| Detroit (Michigan) to Des Moines | 542.29 mi (872.73 km) |
| Denver (Colorado) to Des Moines | 603.02 mi (970.47 km) |
