| Sumter to Stony Brook (New York) | 624.52 mi (1,005.06 km) |
| Sumter to Storm Lake (Iowa) | 1,000.57 mi (1,610.26 km) |
| Sumter to Storrs (Connecticut) | 701.27 mi (1,128.59 km) |
| Sumter to Stoughton (Wisconsin) | 782.44 mi (1,259.21 km) |
| Sumter to Stow (Ohio) | 503.28 mi (809.95 km) |
| Sumter to Streamwood (Illinois) | 700.43 mi (1,127.24 km) |
| Sumter to Streator (Illinois) | 677.67 mi (1,090.60 km) |
| Sumter to Streetsboro (Ohio) | 507.09 mi (816.08 km) |
| Sumter to Strongsville (Ohio) | 515.49 mi (829.60 km) |
| Sumter to Stuart (Florida) | 466.00 mi (749.96 km) |
| Sumter to Stuarts Draft (Virginia) | 291.90 mi (469.77 km) |
| Sumter to Sturgis (Michigan) | 608.03 mi (978.53 km) |
| Sumter to Suamico (Wisconsin) | 844.43 mi (1,358.98 km) |
| Sumter to Sudley (Virginia) | 371.71 mi (598.20 km) |
| Sumter to Suffern (New York) | 602.15 mi (969.07 km) |
