| Sumter to St. Petersburg (Florida) | 445.48 mi (716.93 km) |
| Sumter to St. Simons (Georgia) | 199.38 mi (320.86 km) |
| Sumter to Stafford (Texas) | 938.48 mi (1,510.34 km) |
| Sumter to Stallings (North Carolina) | 82.23 mi (132.33 km) |
| Sumter to Stamford (Connecticut) | 620.29 mi (998.26 km) |
| Sumter to Stanford (California) | 2,337.71 mi (3,762.18 km) |
| Sumter to Stanton (California) | 2,144.74 mi (3,451.63 km) |
| Sumter to Star (Idaho) | 2,038.18 mi (3,280.14 km) |
| Sumter to Starkville (Mississippi) | 485.95 mi (782.06 km) |
| Sumter to State College (Pennsylvania) | 493.40 mi (794.06 km) |
| Sumter to Staten Island (New York) | 572.90 mi (921.99 km) |
| Sumter to Statesboro (Georgia) | 130.96 mi (210.76 km) |
| Sumter to Statesville (North Carolina) | 130.33 mi (209.74 km) |
| Sumter to Staunton (Virginia) | 300.91 mi (484.27 km) |
| Sumter to Steamboat Springs (Colorado) | 1,516.40 mi (2,440.40 km) |
