| Sumter to Southchase (Florida) | 388.64 mi (625.46 km) |
| Sumter to Southern Pines (North Carolina) | 103.28 mi (166.22 km) |
| Sumter to Southfield (Michigan) | 609.96 mi (981.64 km) |
| Sumter to Southgate (Michigan) | 591.13 mi (951.33 km) |
| Sumter to Southlake (Texas) | 967.40 mi (1,556.87 km) |
| Sumter to Spanaway (Washington) | 2,353.12 mi (3,786.98 km) |
| Sumter to Spanish Fork (Utah) | 1,765.78 mi (2,841.75 km) |
| Sumter to Spanish Lake (Missouri) | 640.10 mi (1,030.15 km) |
| Sumter to Spanish Springs (Nevada) | 2,190.80 mi (3,525.75 km) |
| Sumter to Sparks (Nevada) | 2,193.51 mi (3,530.11 km) |
| Sumter to Spartanburg (South Carolina) | 111.55 mi (179.52 km) |
| Sumter to Spearfish (South Dakota) | 1,442.74 mi (2,321.86 km) |
| Sumter to Speedway (Indiana) | 517.78 mi (833.29 km) |
| Sumter to Spencer (Iowa) | 1,017.66 mi (1,637.77 km) |
| Sumter to Spokane (Washington) | 2,130.12 mi (3,428.09 km) |
