| Sumter to Smithville (Missouri) | 870.25 mi (1,400.53 km) |
| Sumter to Smyrna (Delaware) | 455.10 mi (732.42 km) |
| Sumter to Smyrna (Georgia) | 236.53 mi (380.66 km) |
| Sumter to Smyrna (Tennessee) | 374.48 mi (602.67 km) |
| Sumter to Snellville (Georgia) | 207.15 mi (333.37 km) |
| Sumter to Snoqualmie (Washington) | 2,330.20 mi (3,750.10 km) |
| Sumter to Snyder (Texas) | 1,185.62 mi (1,908.06 km) |
| Sumter to Socastee (South Carolina) | 81.36 mi (130.94 km) |
| Sumter to Socorro (Texas) | 1,506.88 mi (2,425.08 km) |
| Sumter to Soddy-Daisy (Tennessee) | 286.72 mi (461.42 km) |
| Sumter to Solana Beach (California) | 2,114.29 mi (3,402.62 km) |
| Sumter to Soledad (California) | 2,301.40 mi (3,703.75 km) |
| Sumter to Solon (Ohio) | 517.72 mi (833.19 km) |
| Sumter to Somers Point (New Jersey) | 490.68 mi (789.67 km) |
| Sumter to Somerset (Kentucky) | 321.60 mi (517.56 km) |
