| Sumter to Scottsbluff (Nebraska) | 1,376.11 mi (2,214.64 km) |
| Sumter to Scottsboro (Alabama) | 326.47 mi (525.41 km) |
| Sumter to Scottsdale (Arizona) | 1,799.61 mi (2,896.20 km) |
| Sumter to Scranton (Pennsylvania) | 576.74 mi (928.17 km) |
| Sumter to Seabrook (Maryland) | 400.00 mi (643.74 km) |
| Sumter to Seabrook (Texas) | 909.85 mi (1,464.26 km) |
| Sumter to Seaford (New York) | 599.55 mi (964.88 km) |
| Sumter to Seagoville (Texas) | 936.08 mi (1,506.48 km) |
| Sumter to Seal Beach (California) | 2,149.74 mi (3,459.68 km) |
| Sumter to Searcy (Arkansas) | 651.01 mi (1,047.70 km) |
| Sumter to Seaside (California) | 2,325.91 mi (3,743.20 km) |
| Sumter to SeaTac (Washington) | 2,350.50 mi (3,782.77 km) |
| Sumter to Seattle (Washington) | 2,353.41 mi (3,787.44 km) |
| Sumter to Sebastian (Florida) | 425.44 mi (684.68 km) |
| Sumter to Sebring (Florida) | 450.90 mi (725.66 km) |
