| Sumter to Santa Paula (California) | 2,197.92 mi (3,537.21 km) |
| Sumter to Santa Rosa (California) | 2,359.15 mi (3,796.69 km) |
| Sumter to Santaquin (Utah) | 1,773.25 mi (2,853.78 km) |
| Sumter to Santee (California) | 2,100.88 mi (3,381.04 km) |
| Sumter to Sapulpa (Oklahoma) | 899.68 mi (1,447.90 km) |
| Sumter to Saraland (Alabama) | 497.61 mi (800.83 km) |
| Sumter to Sarasota (Florida) | 473.59 mi (762.16 km) |
| Sumter to Sarasota Springs (Florida) | 474.51 mi (763.65 km) |
| Sumter to Saratoga (California) | 2,331.35 mi (3,751.94 km) |
| Sumter to Saratoga Springs (New York) | 724.49 mi (1,165.96 km) |
| Sumter to Saratoga Springs (Utah) | 1,781.41 mi (2,866.91 km) |
| Sumter to Sartell (Minnesota) | 1,087.88 mi (1,750.78 km) |
| Sumter to Satellite Beach (Florida) | 398.24 mi (640.90 km) |
| Sumter to Sauk Rapids (Minnesota) | 1,084.55 mi (1,745.41 km) |
| Sumter to Sault Ste. Marie (Michigan) | 891.36 mi (1,434.51 km) |
