| Sumter to Enterprise (Nevada) | 1,966.92 mi (3,165.45 km) |
| Sumter to Enumclaw (Washington) | 2,333.87 mi (3,756.00 km) |
| Sumter to Ephrata (Pennsylvania) | 489.66 mi (788.04 km) |
| Sumter to Erie (Colorado) | 1,418.70 mi (2,283.18 km) |
| Sumter to Erie (Pennsylvania) | 565.28 mi (909.73 km) |
| Sumter to Erlanger (Kentucky) | 420.68 mi (677.02 km) |
| Sumter to Escanaba (Michigan) | 889.07 mi (1,430.82 km) |
| Sumter to Escondido (California) | 2,101.79 mi (3,382.50 km) |
| Sumter to Española (New Mexico) | 1,456.45 mi (2,343.93 km) |
| Sumter to Essex (Maryland) | 430.27 mi (692.46 km) |
| Sumter to Essex Junction (Vermont) | 825.78 mi (1,328.96 km) |
| Sumter to Estelle (Louisiana) | 635.55 mi (1,022.82 km) |
| Sumter to Estero (Florida) | 525.69 mi (846.02 km) |
| Sumter to Euclid (Ohio) | 532.19 mi (856.48 km) |
| Sumter to Eufaula (Alabama) | 309.44 mi (497.99 km) |
