| Sumter to Elyria (Ohio) | 522.27 mi (840.52 km) |
| Sumter to Emeryville (California) | 2,341.23 mi (3,767.85 km) |
| Sumter to Emmaus (Pennsylvania) | 529.12 mi (851.54 km) |
| Sumter to Emporia (Kansas) | 932.21 mi (1,500.25 km) |
| Sumter to Encinitas (California) | 2,113.70 mi (3,401.67 km) |
| Sumter to Endicott (New York) | 610.76 mi (982.93 km) |
| Sumter to Endwell (New York) | 612.93 mi (986.41 km) |
| Sumter to Englewood (Colorado) | 1,412.07 mi (2,272.50 km) |
| Sumter to Englewood (Florida) | 495.32 mi (797.13 km) |
| Sumter to Englewood (New Jersey) | 595.31 mi (958.05 km) |
| Sumter to Englewood (Ohio) | 462.86 mi (744.91 km) |
| Sumter to Enid (Oklahoma) | 1,000.23 mi (1,609.72 km) |
| Sumter to Ennis (Texas) | 945.32 mi (1,521.34 km) |
| Sumter to Ensley (Florida) | 466.00 mi (749.96 km) |
| Sumter to Enterprise (Alabama) | 364.95 mi (587.32 km) |
