| Street to Southern Pines (North Carolina) | 3,831.98 mi (6,166.98 km) |
| Street to Southfield (Michigan) | 3,661.34 mi (5,892.35 km) |
| Street to Southgate (Michigan) | 3,671.05 mi (5,907.98 km) |
| Street to Southlake (Texas) | 4,662.58 mi (7,503.70 km) |
| Street to Spanaway (Washington) | 4,766.16 mi (7,670.40 km) |
| Street to Spanish Fork (Utah) | 4,819.55 mi (7,756.32 km) |
| Street to Spanish Lake (Missouri) | 4,103.01 mi (6,603.16 km) |
| Street to Spanish Springs (Nevada) | 5,103.28 mi (8,212.94 km) |
| Street to Sparks (Nevada) | 5,109.40 mi (8,222.79 km) |
| Street to Spartanburg (South Carolina) | 3,948.75 mi (6,354.89 km) |
| Street to Spearfish (South Dakota) | 4,328.16 mi (6,965.51 km) |
| Street to Speedway (Indiana) | 3,899.82 mi (6,276.15 km) |
| Street to Spencer (Iowa) | 4,085.47 mi (6,574.93 km) |
| Street to Spokane (Washington) | 4,594.00 mi (7,393.32 km) |
| Street to Spokane Valley (Washington) | 4,588.49 mi (7,384.47 km) |
