| Street to Smyrna (Delaware) | 3,489.16 mi (5,615.26 km) |
| Street to Smyrna (Georgia) | 4,107.47 mi (6,610.34 km) |
| Street to Smyrna (Tennessee) | 4,089.55 mi (6,581.49 km) |
| Street to Snellville (Georgia) | 4,086.56 mi (6,576.68 km) |
| Street to Snoqualmie (Washington) | 4,726.03 mi (7,605.80 km) |
| Street to Snyder (Texas) | 4,821.23 mi (7,759.02 km) |
| Street to Socastee (South Carolina) | 3,885.64 mi (6,253.33 km) |
| Street to Socorro (Texas) | 5,080.80 mi (8,176.76 km) |
| Street to Soddy-Daisy (Tennessee) | 4,068.12 mi (6,547.01 km) |
| Street to Solana Beach (California) | 5,399.15 mi (8,689.09 km) |
| Street to Soledad (California) | 5,337.36 mi (8,589.66 km) |
| Street to Solon (Ohio) | 3,636.43 mi (5,852.27 km) |
| Street to Somers Point (New Jersey) | 3,446.45 mi (5,546.53 km) |
| Street to Somerset (Kentucky) | 3,959.22 mi (6,371.75 km) |
| Street to Somerset (New Jersey) | 3,391.00 mi (5,457.29 km) |
