| Street to Scottsboro (Alabama) | 4,133.23 mi (6,651.80 km) |
| Street to Scottsdale (Arizona) | 5,174.37 mi (8,327.34 km) |
| Street to Scranton (Pennsylvania) | 3,401.11 mi (5,473.56 km) |
| Street to Seabrook (Maryland) | 3,554.41 mi (5,720.27 km) |
| Street to Seabrook (Texas) | 4,750.02 mi (7,644.42 km) |
| Street to Seaford (New York) | 3,342.40 mi (5,379.07 km) |
| Street to Seagoville (Texas) | 4,654.09 mi (7,490.03 km) |
| Street to Seal Beach (California) | 5,383.77 mi (8,664.34 km) |
| Street to Searcy (Arkansas) | 4,334.20 mi (6,975.22 km) |
| Street to Seaside (California) | 5,342.07 mi (8,597.23 km) |
| Street to SeaTac (Washington) | 4,743.33 mi (7,633.65 km) |
| Street to Seattle (Washington) | 4,734.14 mi (7,618.87 km) |
| Street to Sebastian (Florida) | 4,233.05 mi (6,812.44 km) |
| Street to Sebring (Florida) | 4,289.65 mi (6,903.52 km) |
| Street to Secaucus (New Jersey) | 3,361.43 mi (5,409.70 km) |
