| Street to Santa Rosa (California) | 5,265.04 mi (8,473.27 km) |
| Street to Santaquin (Utah) | 4,832.15 mi (7,776.59 km) |
| Street to Santee (California) | 5,397.71 mi (8,686.78 km) |
| Street to Sapulpa (Oklahoma) | 4,467.90 mi (7,190.39 km) |
| Street to Saraland (Alabama) | 4,402.65 mi (7,085.38 km) |
| Street to Sarasota (Florida) | 4,343.01 mi (6,989.41 km) |
| Street to Sarasota Springs (Florida) | 4,341.58 mi (6,987.10 km) |
| Street to Saratoga (California) | 5,311.57 mi (8,548.14 km) |
| Street to Saratoga Springs (New York) | 3,255.01 mi (5,238.43 km) |
| Street to Saratoga Springs (Utah) | 4,816.15 mi (7,750.85 km) |
| Street to Sartell (Minnesota) | 3,936.43 mi (6,335.07 km) |
| Street to Satellite Beach (Florida) | 4,218.65 mi (6,789.26 km) |
| Street to Sauk Rapids (Minnesota) | 3,934.96 mi (6,332.71 km) |
| Street to Sault Ste. Marie (Michigan) | 3,533.46 mi (5,686.56 km) |
| Street to Savage (Minnesota) | 3,944.84 mi (6,348.61 km) |
