| Street to Sanford (Maine) | 3,116.73 mi (5,015.89 km) |
| Street to Sanford (North Carolina) | 3,808.84 mi (6,129.74 km) |
| Street to Sanger (California) | 5,266.31 mi (8,475.30 km) |
| Street to Santa Ana (California) | 5,378.43 mi (8,655.75 km) |
| Street to Santa Barbara (California) | 5,400.01 mi (8,690.47 km) |
| Street to Santa Clara (California) | 5,304.27 mi (8,536.39 km) |
| Street to Santa Clara (Oregon) | 4,954.29 mi (7,973.16 km) |
| Street to Santa Clarita (California) | 5,360.51 mi (8,626.91 km) |
| Street to Santa Cruz (California) | 5,328.37 mi (8,575.18 km) |
| Street to Santa Fe (New Mexico) | 4,857.49 mi (7,817.37 km) |
| Street to Santa Fe (Texas) | 4,762.65 mi (7,664.74 km) |
| Street to Santa Fe Springs (California) | 5,373.42 mi (8,647.68 km) |
| Street to Santa Maria (California) | 5,394.74 mi (8,682.00 km) |
| Street to Santa Monica (California) | 5,382.21 mi (8,661.83 km) |
| Street to Santa Paula (California) | 5,382.80 mi (8,662.77 km) |
