| State College to Superior (Colorado) | 1,432.77 mi (2,305.82 km) |
| State College to Superior (Wisconsin) | 817.12 mi (1,315.02 km) |
| State College to Surprise (Arizona) | 1,951.65 mi (3,140.88 km) |
| State College to Susanville (California) | 2,220.27 mi (3,573.18 km) |
| State College to Sussex (Wisconsin) | 556.20 mi (895.12 km) |
| State College to Suwanee (Georgia) | 576.76 mi (928.21 km) |
| State College to Swansea (Illinois) | 662.77 mi (1,066.62 km) |
| State College to Sweetwater (Florida) | 1,047.28 mi (1,685.43 km) |
| State College to Sweetwater (Texas) | 1,371.03 mi (2,206.47 km) |
| State College to Sycamore (Illinois) | 566.86 mi (912.27 km) |
| State College to Sylacauga (Alabama) | 700.58 mi (1,127.47 km) |
| State College to Sylvania (Ohio) | 310.51 mi (499.72 km) |
| State College to Syosset (New York) | 227.74 mi (366.51 km) |
| State College to Syracuse (New York) | 178.65 mi (287.51 km) |
| State College to Syracuse (Utah) | 1,774.23 mi (2,855.35 km) |
