| State College to Southchase (Florida) | 880.58 mi (1,417.16 km) |
| State College to Southern Pines (North Carolina) | 395.85 mi (637.05 km) |
| State College to Southfield (Michigan) | 302.31 mi (486.52 km) |
| State College to Southgate (Michigan) | 293.48 mi (472.30 km) |
| State College to Southlake (Texas) | 1,192.36 mi (1,918.92 km) |
| State College to Spanaway (Washington) | 2,228.18 mi (3,585.91 km) |
| State College to Spanish Fork (Utah) | 1,765.84 mi (2,841.84 km) |
| State College to Spanish Lake (Missouri) | 669.56 mi (1,077.55 km) |
| State College to Spanish Springs (Nevada) | 2,186.10 mi (3,518.19 km) |
| State College to Sparks (Nevada) | 2,190.07 mi (3,524.57 km) |
| State College to Spartanburg (South Carolina) | 460.77 mi (741.53 km) |
| State College to Spearfish (South Dakota) | 1,337.99 mi (2,153.28 km) |
| State College to Speedway (Indiana) | 447.39 mi (720.01 km) |
| State College to Spencer (Iowa) | 901.64 mi (1,451.05 km) |
| State College to Spokane (Washington) | 1,992.93 mi (3,207.32 km) |
