| State College to Scottsbluff (Nebraska) | 1,335.88 mi (2,149.89 km) |
| State College to Scottsboro (Alabama) | 616.61 mi (992.34 km) |
| State College to Scottsdale (Arizona) | 1,920.87 mi (3,091.34 km) |
| State College to Scranton (Pennsylvania) | 121.74 mi (195.92 km) |
| State College to Seabrook (Maryland) | 136.01 mi (218.89 km) |
| State College to Seabrook (Texas) | 1,237.12 mi (1,990.96 km) |
| State College to Seaford (New York) | 228.66 mi (367.98 km) |
| State College to Seagoville (Texas) | 1,174.39 mi (1,889.99 km) |
| State College to Seal Beach (California) | 2,243.41 mi (3,610.42 km) |
| State College to Searcy (Arkansas) | 845.81 mi (1,361.20 km) |
| State College to Seaside (California) | 2,362.95 mi (3,802.80 km) |
| State College to SeaTac (Washington) | 2,220.26 mi (3,573.16 km) |
| State College to Seattle (Washington) | 2,220.49 mi (3,573.53 km) |
| State College to Sebastian (Florida) | 911.09 mi (1,466.26 km) |
| State College to Sebring (Florida) | 942.37 mi (1,516.60 km) |
