| State College to Santa Paula (California) | 2,278.52 mi (3,666.93 km) |
| State College to Santa Rosa (California) | 2,366.48 mi (3,808.47 km) |
| State College to Santaquin (Utah) | 1,775.89 mi (2,858.02 km) |
| State College to Santee (California) | 2,212.90 mi (3,561.32 km) |
| State College to Sapulpa (Oklahoma) | 1,039.32 mi (1,672.62 km) |
| State College to Saraland (Alabama) | 893.82 mi (1,438.46 km) |
| State College to Sarasota (Florida) | 966.98 mi (1,556.20 km) |
| State College to Sarasota Springs (Florida) | 967.91 mi (1,557.71 km) |
| State College to Saratoga (California) | 2,358.13 mi (3,795.04 km) |
| State College to Saratoga Springs (New York) | 262.07 mi (421.76 km) |
| State College to Saratoga Springs (Utah) | 1,776.51 mi (2,859.01 km) |
| State College to Sartell (Minnesota) | 887.04 mi (1,427.54 km) |
| State College to Satellite Beach (Florida) | 885.23 mi (1,424.64 km) |
| State College to Sauk Rapids (Minnesota) | 883.53 mi (1,421.91 km) |
| State College to Sault Ste. Marie (Michigan) | 510.27 mi (821.20 km) |
