| State College to Oskaloosa (Iowa) | 770.26 mi (1,239.62 km) |
| State College to Oswego (Illinois) | 547.67 mi (881.39 km) |
| State College to Oswego (New York) | 196.53 mi (316.28 km) |
| State College to Otsego (Minnesota) | 852.34 mi (1,371.70 km) |
| State College to Ottawa (Illinois) | 572.31 mi (921.05 km) |
| State College to Ottawa (Kansas) | 936.11 mi (1,506.53 km) |
| State College to Ottumwa (Iowa) | 759.71 mi (1,222.63 km) |
| State College to Overland (Missouri) | 679.66 mi (1,093.80 km) |
| State College to Overland Park (Kansas) | 901.10 mi (1,450.19 km) |
| State College to Overlea (Maryland) | 121.36 mi (195.32 km) |
| State College to Oviedo (Florida) | 859.18 mi (1,382.72 km) |
| State College to Owasso (Oklahoma) | 1,017.84 mi (1,638.05 km) |
| State College to Owatonna (Minnesota) | 815.02 mi (1,311.65 km) |
| State College to Owensboro (Kentucky) | 537.47 mi (864.98 km) |
| State College to Owings Mills (Maryland) | 110.69 mi (178.15 km) |
