| State College to Enterprise (Nevada) | 2,034.68 mi (3,274.51 km) |
| State College to Enumclaw (Washington) | 2,207.25 mi (3,552.22 km) |
| State College to Ephrata (Pennsylvania) | 97.61 mi (157.08 km) |
| State College to Erie (Colorado) | 1,425.18 mi (2,293.60 km) |
| State College to Erie (Pennsylvania) | 146.85 mi (236.33 km) |
| State College to Erlanger (Kentucky) | 377.19 mi (607.04 km) |
| State College to Escanaba (Michigan) | 576.51 mi (927.80 km) |
| State College to Escondido (California) | 2,209.14 mi (3,555.27 km) |
| State College to Española (New Mexico) | 1,555.90 mi (2,503.97 km) |
| State College to Essex (Maryland) | 127.11 mi (204.56 km) |
| State College to Essex Junction (Vermont) | 351.21 mi (565.22 km) |
| State College to Estelle (Louisiana) | 1,021.94 mi (1,644.65 km) |
| State College to Estero (Florida) | 1,017.64 mi (1,637.74 km) |
| State College to Euclid (Ohio) | 198.24 mi (319.03 km) |
| State College to Eufaula (Alabama) | 735.05 mi (1,182.95 km) |
