| Spanish Lake to Southchase (Florida) | 879.22 mi (1,414.97 km) |
| Spanish Lake to Southern Pines (North Carolina) | 645.38 mi (1,038.64 km) |
| Spanish Lake to Southfield (Michigan) | 444.32 mi (715.06 km) |
| Spanish Lake to Southgate (Michigan) | 436.88 mi (703.09 km) |
| Spanish Lake to Southlake (Texas) | 559.62 mi (900.61 km) |
| Spanish Lake to Spanaway (Washington) | 1,713.19 mi (2,757.11 km) |
| Spanish Lake to Spanish Fork (Utah) | 1,144.36 mi (1,841.68 km) |
| Spanish Lake to Spanish Springs (Nevada) | 1,571.03 mi (2,528.32 km) |
| Spanish Lake to Sparks (Nevada) | 1,574.23 mi (2,533.48 km) |
| Spanish Lake to Spartanburg (South Carolina) | 528.98 mi (851.31 km) |
| Spanish Lake to Spearfish (South Dakota) | 804.09 mi (1,294.06 km) |
| Spanish Lake to Speedway (Indiana) | 222.81 mi (358.58 km) |
| Spanish Lake to Spencer (Iowa) | 396.40 mi (637.95 km) |
| Spanish Lake to Spokane (Washington) | 1,491.48 mi (2,400.30 km) |
| Spanish Lake to Spokane Valley (Washington) | 1,482.46 mi (2,385.78 km) |
