| Spanish Lake to Enterprise (Nevada) | 1,382.31 mi (2,224.61 km) |
| Spanish Lake to Enumclaw (Washington) | 1,694.02 mi (2,726.27 km) |
| Spanish Lake to Ephrata (Pennsylvania) | 753.33 mi (1,212.37 km) |
| Spanish Lake to Erie (Colorado) | 795.51 mi (1,280.25 km) |
| Spanish Lake to Erie (Pennsylvania) | 579.85 mi (933.17 km) |
| Spanish Lake to Erlanger (Kentucky) | 302.61 mi (487.00 km) |
| Spanish Lake to Escanaba (Michigan) | 506.47 mi (815.08 km) |
| Spanish Lake to Escondido (California) | 1,546.16 mi (2,488.31 km) |
| Spanish Lake to Española (New Mexico) | 890.39 mi (1,432.94 km) |
| Spanish Lake to Essex (Maryland) | 738.67 mi (1,188.77 km) |
| Spanish Lake to Essex Junction (Vermont) | 964.13 mi (1,551.62 km) |
| Spanish Lake to Estelle (Louisiana) | 617.98 mi (994.54 km) |
| Spanish Lake to Estero (Florida) | 983.33 mi (1,582.52 km) |
| Spanish Lake to Euclid (Ohio) | 497.50 mi (800.65 km) |
| Spanish Lake to Eufaula (Alabama) | 553.91 mi (891.43 km) |
