| Southborough to University Place (Washington) | 4,841.66 mi (7,791.90 km) |
| Southborough to Upland (California) | 5,446.62 mi (8,765.48 km) |
| Southborough to Upper Arlington (Ohio) | 3,881.20 mi (6,246.19 km) |
| Southborough to Upper Grand Lagoon (Florida) | 4,462.25 mi (7,181.30 km) |
| Southborough to Upper Montclair (New Jersey) | 3,487.28 mi (5,612.23 km) |
| Southborough to Urbana (Illinois) | 4,078.12 mi (6,563.11 km) |
| Southborough to Urbana (Maryland) | 3,682.11 mi (5,925.79 km) |
| Southborough to Urbana (Ohio) | 3,904.55 mi (6,283.77 km) |
| Southborough to Urbandale (Iowa) | 4,216.30 mi (6,785.48 km) |
| Southborough to Utica (New York) | 3,433.41 mi (5,525.54 km) |
| Southborough to Uvalde (Texas) | 5,075.47 mi (8,168.18 km) |
| Southborough to Vacaville (California) | 5,335.91 mi (8,587.31 km) |
| Southborough to Vadnais Heights (Minnesota) | 4,028.00 mi (6,482.44 km) |
| Southborough to Vail (Arizona) | 5,328.90 mi (8,576.04 km) |
| Southborough to Valdosta (Georgia) | 4,326.33 mi (6,962.56 km) |
